As of today there's [an active thread][1] where Unity and MS are working together to address Windows Defender reporting "Trojan:Win32/Maltule.C!cl" for Unity builds, on both Win7 and Win10. Please see the linked thread for details and submit a report to moderator Tautvydas-Zilys if your issue fits the bill.
[1]: https://forum.unity3d.com/threads/unity-producing-malware-under-windows10.421312/
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